I'm out! Have to sleep tonight. Please (!!!) remind me tomorrow (when TLSA jumps to 250+) that profit-taking is ok.
Taking profit isn't just OK, it's the ultimate point of short-term options trades. I too have learned that for my portfolio, weekly options and other short-term instruments are to be used to take advantage of overly large price movements that one expects to reverse, or particular data that the market is not interpreting correctly, only when one has a sound thesis to back them up. Otherwise, might as well be in Vegas.
As for core shares, no I don't think it's wise to move in and out of those with great frequency. Have a strategy that isn't just following the herd, buy and hold for the long-term investment thesis, and never risk what you can't afford to lose.
Caveat: I am not a financial advisor, please invest at your own risk and don't do what I say.