22 are usually heavier, it’s also sprung weight too. It’s the worst weight you can have. You will need more power to spin it
If the tires are wider, they will add friction, adding to the energy consumption.
The factory Speedo is very accurate on the 20” x. If you want to keep your speedo the same, you have to make sure the tire diameter is the same. You can find it by looking at tire racks specs