The original seal between the fixed pane (or quarter pane depending on what you want to call it) changed sometime after my 2017 S75D was built. Last year a deer t-boned my car, and destroyed the drivers side mirror, dented both front & rear drivers side doors, and barely bent the frame the fixed pane is attached to.
This caused the occasional wind noise I would have to change to a constant scream. The body shop didn't replace the fixed pane & door seals, and I refused to take it back after they screwed up on the repair in general. I had the insurance company cut me a check for the cost of the parts from Tesla, and I swapped them myself. What I found is that on the vertical seal attached to that fixed pane, Tesla had started inserting a section of silicone tubing inside the seal, which "stiffens" where the drivers or passenger window glides against it. Other than that, the seal is still the same. I checked the original seal, as well as the one on the passenger side door, and both were missing this "reinforcement." I ended up just replacing the fixed pane & that one seal, and returned the main door seal as after the replacement seal was installed, ALL of the wind noise that I would have from that fixed pane was gone, and has not yet returned.
Prior to the accident, I could count on a bit of wind noise from the drivers side once I got to 70mph, but the passenger side would only do it sometimes. I didn't want to shell out the cost for a new seal, so I sacrificed a fat silicone straw (~0.5" OD) and shoved it on in there before putting everything back together. Sure enough, the wind noise on the passenger side was gone as well.
Here are a couple pictures to show were it is inserted/etc. If you do this, use lots of lube.....TRUST ME. It's a real pain to insert the tubing, but becomes a nightmare to "snap" the seal back into the grooves if it's dry. I used a white lithium grease spray that I had around, and it worked like a charm.
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